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1

Very high density of CHO cells in perfusion by ATF or TFF in WAVE bioreactor™. Part I. Effect of the cell density on the process

Clincke, Marie-Françoise, Mölleryd, Carin, Zhang, Ye, Lindskog, Eva, Walsh, Kieron, Chotteau, Véronique

Journal:

Biotechnology Progress

Year:

2013

Language:

english

File:

PDF, 2.69 MB

english, 2013

2

From Clone Selection to 80L Bioreactor Production: Better, Faster, Leaner

Clincke, Marie-Françoise, Delouvroy, Frédéric, Révérend, Guillaume L, Stofferis, Jimmy, Hinchliffe, Matthew, Malphettes, Laetitia

Journal:

BMC Proceedings

Year:

2015

Language:

english

File:

PDF, 298 KB

english, 2015

3

Effect of surfactant pluronic F-68 on CHO cell growth, metabolism, production, and glycosylation of human recombinant IFN-γ in mild operating conditions

Marie-Françoise Clincke, Emmanuel Guedon, Frances T. Yen, Virginie Ogier, Olivier Roitel, Jean-Louis Goergen

Journal:

Biotechnology Progress

Year:

2011

Language:

english

File:

PDF, 771 KB

english, 2011

4

Very high density of Chinese hamster ovary cells in perfusion by alternating tangential flow or tangential flow filtration in WAVE bioreactor™-part II: Applications for antibody production and cryopreservation

Clincke, Marie-Françoise, Mölleryd, Carin, Samani, Puneeth K, Lindskog, Eva, Fäldt, Eric, Walsh, Kieron, Chotteau, Véronique

Journal:

Biotechnology Progress

Year:

2013

Language:

english

File:

PDF, 2.44 MB

english, 2013

5

Feeding strategy optimization in interaction with target seeding density of a fed-batch process for monoclonal antibody production

Clincke, Marie-Françoise, Mathy, Grégory, Gimenez, Laura, Le Révérend, Guillaume, Fessler, Boris, Stofferis, Jimmy, Yahia, Bassem, Bonsu-Dartnall, Nicola, Malphettes, Laetitia

Journal:

BMC Proceedings

Year:

2013

Language:

english

File:

PDF, 348 KB

english, 2013

6

A chiral separation strategy for acidic drugs in capillary electrochromatography using both chlorinated and nonchlorinated polysaccharide-based selectors

Albals, Dima, Hendrickx, Ans, Clincke, Lies, Chankvetadze, Bezhan, Heyden, Yvan Vander, Mangelings, Debby

Journal:

ELECTROPHORESIS

Year:

2014

Language:

english

File:

PDF, 601 KB

english, 2014

7

Transgenic mouse model for the fragile X syndrome

Kooy, R. Frank, D'Hooge, Rudi, Reyniers, Edwin, Bakker, Cathy E., Nagels, Guy, De Boulle, Kristel, Storm, Katrien, Clincke, Gilbert, De Deyn, Peter P., Oostra, Ben A., Willems, Patrick J.

Journal:

American Journal of Medical Genetics

Year:

1996

Language:

english

File:

PDF, 513 KB

english, 1996

8

Anticonvulsant profile of flunarizine

Dr. Albert Wauquier, David Ashton, Gilbert Clincke, Joannes Fransen, Jean-Marie Gillardin, A. J. Paul Janssen

Journal:

Drug Development Research

Year:

1986

Language:

english

File:

PDF, 632 KB

english, 1986

9

R 58 735: A new antihypoxic drug with anticonvulsant properties and possible effects on cognitive functions

Dr. Albert Wauquier, Gilbert Clincke, David Ashton, Marc De Ryck, Joannes Fransen, Gust van Clemen

Journal:

Drug Development Research

Year:

1986

Language:

english

File:

PDF, 483 KB

english, 1986

10

R 58 735, a novel antihypoxic drug improves memory in rats

Gilbert Clincke, Arjun Sahgal

Journal:

Drug Development Research

Year:

1986

Language:

english

File:

PDF, 334 KB

english, 1986

11

Does AAMI constitute a real disease entity? A placebo-controlled double-blind study with sabeluzole (R58 735) in a patient population with real memory problems

Luc Tritsmans, Gilbert Clincke, Boudewijn Peelmans

Journal:

Drug Development Research

Year:

1990

Language:

english

File:

PDF, 618 KB

english, 1990

12

Long-term follow-up treatment with sabeluzole in elderly patients with pronounced memory problems of unknown origin

Gilbert Clincke, Dr. Luc Tritsmans, Boudewijn Peelmans

Journal:

Drug Development Research

Year:

1991

Language:

english

File:

PDF, 302 KB

english, 1991

13

In vivo studies on the mechanism of action of the broad spectrum anticonvulsant loreclezole

David Ashton, Joannes Fransen, Jan Heeres, Gilbert H.C. Clincke, Paul A.J. Janssen

Journal:

Epilepsy Research

Year:

1992

Language:

english

File:

PDF, 708 KB

english, 1992

14

Cerebral resuscitation: Pathophysiology and therapy

A. Wauquier, H.L. Edmonds Jr., G.H.C. Clincke

Journal:

Neuroscience & Biobehavioral Reviews

Year:

1987

Language:

english

File:

PDF, 1.92 MB

english, 1987

15

Effect of iron sources on the glycosylation macroheterogeneity of human recombinant IFN-γ produced by CHO cells during batch processes

Marie-Françoise Clincke, Emmanuel Guedon, Frances T Yen, Virginie Ogier, Jean-Louis Goergen

Journal:

BMC Proceedings

Year:

2011

Language:

english

File:

PDF, 114 KB

english, 2011

16

Study of a recombinant CHO cell line producing a monoclonal antibody by ATF or TFF external filter perfusion in a WAVE Bioreactor™

Marie-Françoise Clincke, Carin Mölleryd, Ye Zhang, Eva Lindskog, Kieron Walsh, Véronique Chotteau

Journal:

BMC Proceedings

Year:

2011

Language:

english

File:

PDF, 181 KB

english, 2011

17

Characterization of metalloprotease and serine protease activities in batch CHO cell cultures: control of human recombinant IFN-γ proteolysis by addition of iron citrate

Marie-Françoise Clincke, Emmanuel Guedon, Frances T Yen, Virginie Ogier, Jean-Louis Goergen

Journal:

BMC Proceedings

Year:

2011

Language:

english

File:

PDF, 132 KB

english, 2011

18

The effect of sabeluzole (R 58735) on memory retrieval functions

L. Tritsmans, G. Clincke, W. K. Amery

Journal:

Psychopharmacology

Year:

1988

Language:

english

File:

PDF, 425 KB

english, 1988

19

Sabeluzole (R 58 735) increases consistent retrieval during serial learning and relearning of nonsense syllables

G. H. C. Clincke, L. Tritsmans

Journal:

Psychopharmacology

Year:

1988

Language:

english

File:

PDF, 208 KB

english, 1988

20

Metrazol-produced impairment of passive avoidance retention specifically antagonized by anti-petit mal drugs

G. Clincke, A. Wauquier

Journal:

Psychopharmacology

Year:

1979

Language:

english

File:

PDF, 265 KB

english, 1979

21

A comparison of different methods of assessing patterns of responding in discrete trial choice procedures

A. Sahgal, G. H. C. Clincke

Journal:

Psychopharmacology

Year:

1985

Language:

english

File:

PDF, 417 KB

english, 1985

22

The effect of R 58 735 (Sabeluzole) on memory functions in healthy elderly volunteers

G. H. C. Clincke, L. Tritsmans, C. Idzikowski, W. K. Amery, P. A. J. Janssen

Journal:

Psychopharmacology

Year:

1988

Language:

english

File:

PDF, 560 KB

english, 1988

23

Effects of ritanserin and chlordiazepoxide on sleep-wakefulness alterations in rats following chronic cocaine treatment

Christine Dugovic, Theo F. Meert, David Ashton, Gilbert H. C. Clincke

Journal:

Psychopharmacology

Year:

1992

Language:

english

File:

PDF, 888 KB

english, 1992

24

Single-dose and steady-state pharmacokinetics of sabeluzole in senile dementia of Alzheimer type patients

P. P. De Deyn, V. Van de Velde, W. Verslegers, J. Saerens, B. A. Pickut, B. Clincke, R. Woestenborghs, A. Van Peer

Journal:

European Journal of Clinical Pharmacology

Year:

1992

Language:

english

File:

PDF, 278 KB

english, 1992

25

Lacosamide

Yasothan, Uma, Clincke, Gilbert, Kirkpatrick, Peter, Perucca, Emilio

Journal:

Nature Reviews Drug Discovery

Year:

2008

Language:

english

File:

PDF, 248 KB

english, 2008

26

Altered Na+-channel function as an in vitro model of the ischemic penumbra: action of lubeluzole and other neuroprotective drugs

David Ashton, Roland Willems, Jozef Wynants, Jos Van Reempts, Roger Marrannes, Gilbert Clincke

Journal:

Year:

1997

Language:

english

File:

PDF, 607 KB

english, 1997

27

Neocortical localization of tactile/proprioceptive limb placing reactions in the rat

March De Ryck, Jos Van Reempts, Hilde Duytschaever, Bruno Van Deuren, Gilbert Clincke

Journal:

Year:

1992

Language:

english

File:

PDF, 5.59 MB

english, 1992

28

Parameter selection in a rate free test of brain self-stimulation: Towards an alternative interpretation of drug effects

Albert Wauquier, Gilbert H.C Clincke, Joannes F Fransen

Journal:

Behavioural Brain Research

Year:

1983

Language:

english

File:

PDF, 568 KB

english, 1983

29

The effect of hypoxia on the acquisition of a two-way avoidance task in the guinea-pig

G.H.C. Clincke, A. Wauquier

Journal:

Behavioural Brain Research

Year:

1984

Language:

english

File:

PDF, 544 KB

english, 1984

30

Pharmacological protection against hypoxia-induced effects on medium-term memory in a two-way avoidance paradigm

G.H.C. Clincke, A. Wauquier

Journal:

Behavioural Brain Research

Year:

1984

Language:

english

File:

PDF, 335 KB

english, 1984

31

The effects of repeated intense hypoxia on learning and memory in the guinea pig

Journal:

Behavioural Brain Research

Year:

1986

Language:

english

File:

PDF, 116 KB

english, 1986

32

Stress during cell culture processes

Joseph Boudrant, Naziha Barbouche, Nasir Mehmood, Kenza Boulaya, Marie-Françoise Clincke, Eric Olmos, Stéphane Delaunay, Jean-Louis Goergen, Emmanuel Guédon, Annie Marc

Journal:

Journal of Biotechnology

Year:

2008

Language:

english

File:

PDF, 47 KB

english, 2008

33

Prenatal stress induces long-term sleep alterations in adult rats: Implication for depression

C. Dugovic, S. Maccari, G. Clincke, O. Van Reeth

Journal:

European Neuropsychopharmacology

Year:

1998

Language:

english

File:

PDF, 182 KB

english, 1998

34

Action of lubeluzole and other neuroprotective drugs on Na+-dependent Ca2+-overload induced by veratridine in the CA1 region of hippocampal slices

D. Ashton, R. Willems, R. Marrannes, G.H.C. Clincke

Journal:

Pharmacological Research

Year:

1995

Language:

english

File:

PDF, 162 KB

english, 1995

35

Lubeluzole blocks increases in extracellular glutamate and taurine in the peri-infarct zone in rats

Dieter K.A Scheller, Marc De Ryck, Jochen Kolb, Stephan Szathmary, Jos van Reempts, Gilbert Clincke, Frank Tegtmeier

Journal:

European Journal of Pharmacology

Year:

1997

Language:

english

File:

PDF, 748 KB

english, 1997

36

Synaptic plasticity in rat hippocampus associated with learning

Jos Van Reempts, Margarita Dikova, Leen Werbrouck, Gilbert Clincke, Marcel Borgers

Journal:

Behavioural Brain Research

Year:

1992

Language:

english

File:

PDF, 1.15 MB

english, 1992

37

Brain Ischemia as a Target for Ca2+ Entry Blockers

A. WAUQUIER, D. ASHTON, G. H. C. CLINCKE

Journal:

Annals of the New York Academy of Sciences

Year:

1988

Language:

english

File:

PDF, 806 KB

english, 1988

38

Evidence for a Possible Role of the 5-HT2 Antagonist Ritanserin in Drug Abuse

T. MEERT, G. CLINCKE

Journal:

Annals of the New York Academy of Sciences

Year:

1992

Language:

english

File:

PDF, 164 KB

english, 1992

39

Process development and optimization of fed-batch production processes for therapeutic proteins by CHO cells

Clincke, Marie-Françoise, Harmsen, Mareike, Malphettes, Laetitia

Journal:

BMC Proceedings

Year:

2013

Language:

english

File:

PDF, 511 KB

english, 2013

40

Protective and resuscitative properties of flunarizine

Wauquier, A., Ashton, D., Clincke, G., Edmonds, H.L.

Journal:

International Journal of Developmental Neuroscience

Year:

1985

Language:

english

File:

PDF, 80 KB

english, 1985

41

Anticonvulsant profile of flunarizine

Clincke, G., Ashton, D., Wauquier, A.

Journal:

International Journal of Developmental Neuroscience

Year:

1985

Language:

english

File:

PDF, 77 KB

english, 1985

42

Three versus five micrometer chlorinated polysaccharide-based packings in chiral capillary electrochromatography: efficiency and precision evaluation

Hendrickx, Ans, Klerck, Katrijn De, Mangelings, Debby, Clincke, Lies, Heyden, Yvan Vander

Journal:

Biomedical Chromatography

Year:

2014

Language:

english

File:

PDF, 360 KB

english, 2014

43

Three versus five micrometer chlorinated polysaccharide-based packings in chiral capillary electrochromatography: performance evaluation

Hendrickx, Ans, De Klerck, Katrijn, Mangelings, Debby, Clincke, Lies, Heyden, Yvan Vander

Journal:

Biomedical Chromatography

Year:

2014

Language:

english

File:

PDF, 628 KB

english, 2014

44

Contact allergy caused by Tinosorb ® M: let us not forget about xanthan gum

Aerts, Olivier, Clinck, Babette, Schramme, Martine, Lambert, Julien

Journal:

Contact Dermatitis

Year:

2015

Language:

english

File:

PDF, 661 KB

english, 2015

45

SOMATODENDRITIC 5-HT1A RECEPTORS ARE CRITICALLY INVOLVED IN THE ANXIOLYTIC EFFECTS OF 8-OH-DPAT IN RATS

MEERT, T F, DE, HAES P, AERTS, A, CLINCKE, G

Journal:

Behavioural Pharmacology

Year:

1996

File:

PDF, 208 KB

1996

46

A PHARMACOLOGICAL EVALUATION OF ACUTE AND REPEATED DRUG TREATMENT IN RODENT MODELS FOR ANTIDEPRESSANTS

MEERT, T F, HUYSMANS, H, CLINCKE, G

Journal:

Behavioural Pharmacology

Year:

1996

File:

PDF, 106 KB

1996

47

Quantification of tremor sensitivity and inhibition of exploratory behaviour during alcohol withdrawal in rats

Meert, T. F., Rassnick, S., Huysmans, H., Peeters, J., Clincke, G. H.C.

Journal:

Behavioural Pharmacology

Year:

1992

File:

PDF, 593 KB

1992

48

PHARMACOLOGICAL EVALUATION OF AN AUTOMATED SOCIAL DRINKING/DOMINANCE TEST IN RATS

Meert, T. F., Seghers, S., Aerts, N., Clincke, G.

Journal:

Behavioural Pharmacology

Year:

1998

File:

PDF, 197 KB

1998

49

GALANTAMINE LACKS STIMULANT AND NARCOTIC CUEING PROPERTIES IN RATS

Clincke, G., Aerts, N., Meert, T. F.

Journal:

Behavioural Pharmacology

Year:

1998

File:

PDF, 201 KB

1998

50

THE ROLE OF DOPAMINE DI AND D2 ANTAGONISM IN THE DISCRIMINATIVE-STIMULUS PROPERTIES OF COCAINE

MEERT, T F, MELIS, W, CALLAERTS, K, NARANJI, F, CLINCKE, G

Journal:

Behavioural Pharmacology

Year:

1996

File:

PDF, 106 KB

1996

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